(S)-4-cloro-3-hidroxi-butanenitrilo (CAS 127913-44-4) é uma impureza quiral com ocorrência relevante em rotas sintéticas de nitrilos clorados | caracterizada pela configuração (S) e por propriedades físico-químicas críticas para controle analítico | como polaridade moderada | solubilidade em solventes orgânicos polares e sensibilidade à hidrólise. Sua detecção e quantificação são tipicamente realizadas por HPLC quiral | LC-MS e RMN 1H/13C | permitindo monitoramento em níveis traço. Avaliação de estabilidade sob condições ácidas e básicas é recomendada devido ao risco de epimerização ou degradação. Dados sobre ponto de fusão | tempo de retenção e espectrometria de massas são essenciais para métodos de controle de qualidade e avaliação toxicológica.
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