Acetylcysteine Impurity 1 (sal sódica), CAS 15058-19-2, é o sal de sódio de um tiolcarboxilato relacionado à acetilcisteína, com fórmula molecular C5H6NNaO2S e massa molar de 167,16 g/mol. A espécie é compatível com uma impureza de processo ou de degradação, gerada por desacetilação, oxidação do tiol ou troca de sal durante a síntese e o armazenamento de intermediários mucolíticos sulfurados. Devido à elevada polaridade, sua identificação e quantificação costumam exigir LC-MS/MS, cromatografia iônica e RMN, enquanto a aplicação direta de GC-MS é limitada. Em contexto regulatório, avalia-se estabilidade oxidativa, deriva composicional e estabelecimento de limites de especificação, e não um alerta genotóxico intrínseco.
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