Cefaclor EP Impurity D, também designada Cefaclor delta-3-isomer, é um isómero estrutural do antibiótico cefalosporínico cefaclor, e não uma classe heterocíclica distinta. O CAS 152575-13-8 identifica esta substância relacionada com fórmula molecular C15H14ClN3O4S e massa molecular de 367.80 g/mol. A impureza é compatível com isomerização ocorrida durante a síntese ou o armazenamento, por rearranjo no núcleo cephem que altera a posição da dupla ligação sem modificar a composição elementar. A caracterização normalmente exige métodos ortogonais como HPLC com deteção por arranjo de díodos, LC-MS/MS e, quando necessário, RMN, para resolver a isomeria posicional e quantificar vestígios com rigor farmacopéico.
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