Cefdinir Decarboxy Open Ring Lactone (CAS 178949-04-7) é uma impureza de degradação estruturalmente relacionada ao cefdinir, cefalosporina de terceira geração, formada por abertura do anel β-lactâmico seguida de rearranjo por descarboxilação e lactonização. Com fórmula molecular C13H15N5O4S2 e massa molecular de 369.42 g/mol, preserva o motivo sulfurado dihidrotiazínico, porém perde o farmacóforo cepêmico íntegro. A sua formação é compatível com vias hidrolíticas e induzidas por estresse durante armazenamento ou processamento. Devido ao caráter polar e não volátil, a caracterização costuma exigir LC-MS/MS, LC-MS de alta resolução e perfilamento de impurezas por HPLC em fase reversa com detecção por arranjo de diodos ou MS. Não se trata de uma nitrosamina, mas é relevante para controles indicativos de estabilidade.
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