Impureza 2-Bromo-1-[4-hydroxy-3-(hydroxymethyl)phenyl]ethan-1-one (CAS 62932-94-9) é um subproduto brominado frequentemente observado em sínteses de cetonas fenílicas. Caracteriza-se por presença de grupamento bromo no carbono alfa e por hidroxila e hidroximetila no anel aromático | afetando polaridade e retenção por HPLC. Identificação robusta requer LC-MS para massa molecular | 1H/13C NMR para padrões de substituição e espectroscopia FTIR para funções carbonila e hidroxila. Forma-se por bromação lateral ou por degradação oxidativa e deve ser monitorada por limites de especificação típicos abaixo de 0 | 1% para evitar impacto na pureza do produto. Estratégias de controle incluem otimização de etapas de bromação | lavagens seletivas e cromatografia de purificação.
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