3-Aminopyridine (CAS 462-08-8) | também referida como 3-Pyridinamine | m-Aminopyridine | 3-Pyridylamine ou pyridin-3-yl-amine | é uma impureza aromática básica de baixo peso molecular frequentemente encontrada em processos sintéticos envolvendo anéis de piridina. Como amina primária heteroaromática apresenta polaridade elevada e forte absorção UV | o que facilita sua detecção por HPLC-UV | LC-MS e RMN | além de possibilidade de análise por GC após derivatização. Devido ao impacto potencial sobre perfil toxicológico e estabilidade do produto final | recomenda-se definição de limites de especificação | validação de métodos analíticos e estratégias de remoção como recristalização | cromatografia e troca iônica.
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