5-Oxo Atorvastatin, CAS 1391052-82-6, é uma impureza oxidativa do arcabouço das estatinas, caracterizada pela formação de cetona na posição 5 da cadeia lateral heptanoica baseada em pirrol. A fórmula molecular C33H33FN2O5 corresponde a uma massa molecular de 556,62 g/mol, compatível com um derivado monooxigenado da atorvastatina. Sua formação está geralmente associada à degradação oxidativa durante síntese, armazenamento ou exposição a estresse, e não a um intermediário intencional. A elucidação estrutural e a quantificação em nível traço normalmente requerem LC-MS/MS, HRMS e métodos HPLC indicativos de estabilidade, com RMN para atribuição definitiva. É relevante para o perfil de impurezas em संद frameworks farmacopéicos e ICH Q3A/Q3B.
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