Apixaban Related Compound F, CAS 536759-91-8, é Ethyl 1-(4-methoxyphenyl)-6-(4-nitrophenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylate, uma impureza de pirazolopiridinona substituída com fórmula molecular C22H20N4O6 e massa molecular de 436.42 g/mol. A sua arquitetura contém um grupo arilo nitroaromático e um núcleo heterocíclico esterificado, compatível com um intermediário ou subproduto de síntese gerado durante a montagem do esqueleto da apixabana. Como impurezas nitroaromáticas podem exigir avaliação de genotoxicidade segundo ICH M7, a caracterização em nível de traço depende normalmente de LC-MS/MS, espectrometria de massa de alta resolução e HPLC ortogonal, uma vez que a deteção por UV frequentemente não oferece especificidade suficiente.
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