Tetrahydro-2H-pyran-2-ol (CAS 694-54-2) | também conhecido como 2-hidroxitetrahidropiran | é uma impureza polar frequentemente detectada em sínteses envolvendo anéis oxigenados. Apresenta alta solubilidade em solventes polares e perfil analítico característico por GC com derivatização | LC-MS | RMN e espectroscopia IR. Sua presença sinaliza hidratação indesejada ou reações de redução ou oxidação incompletas | podendo afetar estabilidade e pureza do lote. O controle exige quantificação por métodos validados | especificação de limites e remoção por destilação fracionada | extração ou cromatografia para cumprir requisitos regulatórios de qualidade.
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