2-Methyl-4-nitroimidazole, 2-Methyl-5-nitroimidazole; Metronidazole Benzoate Imp. B (EP), Tinidazole Imp. A (EP), Metronidazole Imp. A (EP), Tinidazole USP Related Compound A, Tinidazole USP RC A, Tinidazole Related Compound A, Metronidazole Benzoate Impurity B, Metronidazole Impurity A, Tinidazole Impurity A
Descrição
Metronidazol Impureza A CRS (CAS 696-23-1) | também referida como 2-Metil-4-nitroimidazol ou 2-Metil-5-nitroimidazol | é uma impureza do tipo nitroimidazol relevante em formulações e processos de síntese. Apresenta perfil físico-químico bem definido com sinais espectroscópicos característicos do anel imidazólico e do grupo nitro | detectáveis por HPLC-UV | LC-MS | RMN e espectroscopia IR. Sua origem decorre de subprodutos sintéticos ou rotas de degradação e por isso exige monitoramento de estabilidade e determinação de limites em conformidade com farmacopeias. O conhecimento do seu comportamento cromatográfico e térmico é essencial para avaliação de pureza e investigação de desvios no processo.
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