6-Oxo Estriol (CAS 7323-86-6) | também conhecido como Oestriol-6-one ou 6-Ketoestriol | é uma impureza relevante em síntese de derivados estrogênicos | caracterizada por oxidação na posição 6 que altera polaridade e comportamento cromatográfico. A presença desta impureza exige métodos analíticos sensíveis como HPLC com detecção UV ou LC-MS/MS para quantificação e confirmação estrutural | além de validação de retenção relativa e limiares de identificação. Sua formação está associada a condições oxidativas e impurezas de partida | impactando estabilidade e perfil de segurança do produto final. Estratégias de controle incluem otimização sintética | purificação cromatográfica e limites especificados em controle de qualidade para conformidade regulatória.
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