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Documentation
Inclui: HPLC, MASS/LC-MS, RMN de 1H, FT-IR, teor, Relatório de Elucidação Estrutural (SER) e dados analíticos adicionais dependendo do produto.
1231930-82-7Abemaciclib Mesylate
● Under Development
| Nº do catálogo: | VL4990001 |
|---|---|
| Nº CAS: | 1231930-82-7 |
| Fórmula Mol.:: | C₂₈H₃₆F₂N₈O₃S |
| Peso Mol.:: | 602.7 g/mol |
Informações adicionais sobre o CAS 1231930-82-7
Fármaco de origem
AbemaciclibNome IUPAC
N-[5-[(4-Ethyl-1-piperazinyl)methyl]-2-pyridinyl]-5-fluoro-4-[4-fluoro-2-methyl-1-(1-methylethyl)-1H-benzimidazol-6-yl]-2-pyrimidinamine MethanesulfonateSinônimos farmacopeicos
N/AOutros sinônimos
Abemaciclib Methanesulfonate; N-(5-((4-ethylpiperazin-1-yl)methyl)pyridin-2-yl)-5-fluoro-4-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)pyrimidin-2-amine methanesulfonate; 2-Pyrimidinamine, N-(5-((4-ethyl-1-piperazinyl)methyl)-2-pyridinyl)-5-fluoro-4-(4-fluoro-2-methyl-1-(1-methylethyl)-1H-benzimidazol-6-yl)-, methanesulfonate (1:1); N-[5-[(4-ethylpiperazin-1-yl)methyl]pyridin-2-yl]-5-fluoro-4-(7-fluoro-2-methyl-3-propan-2-ylbenzimidazol-5-yl)pyrimidin-2-amine;methanesulfonic acid; Methanesulfonic acid–N-{5-[(4-ethylpiperazin-1-yl)methyl]pyridin-2-yl}-5-fluoro-4-[4-fluoro-2-methyl-1-(propan-2-yl)-1H-benzimidazol-6-yl]pyrimidin-2-amine (1/1)Descrição
Impureza associada ao Abemaciclib Mesilato (CAS 1231930-82-7) refere-se tipicamente a subprodutos de síntese e variantes de sal | incluindo isômeros regioquímicos | formas N-desalquiladas | produtos de desfluoração e impurezas de contraíon metanossulfônico. O perfil de impurezas influencia estabilidade | solubilidade e conformidade com especificações | por isso é avaliado por HPLC com detecção UV | LC-MS e RMN para identificação estrutural e quantificação. Estratégias de controlo incluem otimização de etapas sintéticas | purificação por recristalização | trocas iônicas e estabelecimento de limites de aceitação por lote. A documentação robusta do perfil garante rastreabilidade e consistência do material.
Referências
Kim, Esther S. “Abemaciclib: First Global Approval.” Drugs, vol. 77, no. 18, Nov. 2017, pp. 2063–70, https://doi.org/10.1007/s40265-017-0840-z.Solicitar orçamento
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