Furan-2-carbothioic Acid (CAS 527-72-0) é uma impureza heterocíclica frequentemente identificada em sínteses envolvendo furanos e derivados tiofuncionais; como impureza apresenta propriedades físico-químicas específicas | como ponto de fusão moderado | solubilidade em solventes orgânicos e assinaturas analíticas distintos por UV e espectrometria de massas | o que permite sua detecção por HPLC | GC-MS e LC-MS/MS; a sua presença pode impactar rendimento | perfil toxicológico e estabilidade do produto final | exigindo validação analítica para quantificação em níveis traço e estabelecimento de limites de aceitação conforme guidelines ICH; estratégias de controle incluem otimização das etapas de reação | purificação cromatográfica e monitoramento da estabilidade para minimizar formação e acúmulo.
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