Monoacetin (CAS 26446-35-5) é uma impureza lipofílica resultante da acetilação parcial do glicerol | com impacto direto em parâmetros de qualidade e estabilidade de matérias primas e intermediários; sua presença altera viscosidade | ponto de fusão e perfil de impurezas | exigindo monitoramento por cromatografia líquida e gasosa combinadas com espectrometria de massas e métodos validados. Estudos de degradação térmica e reatividade com solventes orientam estratégias de controle | como otimização de purificação e condições de armazenamento. Relatórios de qualidade devem quantificar Monoacetin com precisão | estabelecer limites aceitáveis e validar métodos analíticos para garantir conformidade regulatória.
Referências
“Sustere, Z., Kampare, R., Liepins, E., & Kampars, V. (2014). The composition of commercial acetylated glycerol samples determined by 13C and 1H NMR. The comparison with gas chromatography. Journal of Analytical Chemistry, 69(8), 763–768. https://doi.org/10.1134/s1061934814080103 ”
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