Informações adicionais sobre o N-methyl-N-nitrosopropane-1 | 3-diamine
Fármaco de origem
Nitroso inhouse impurity
Nome IUPAC
N-methyl-N-nitrosopropane-1,3-diamine
Sinônimos
N/A
SMILES
NCCCN(C)N=O
InChI
InChI=1S/C4H11N3O/c1-7(6-8)4-2-3-5/h2-5H2,1H3
Descrição
N-methyl-N-nitrosopropane-1,3-diamine é uma impureza do tipo nitrosamina com fórmula molecular C4H11N3O e massa molecular de 117,09 g/mol. Estruturalmente, apresenta a função N-nitroso em um arcabouço amino, motivo associado à ativação metabólica para espécies eletrofílicas e, portanto, a preocupação genotóxica no contexto das diretrizes ICH M7. Compostos dessa classe podem formar-se sob condições nitrosantes durante síntese, processamento ou armazenamento quando precursores amínicos entram em contato com nitrito. A determinação em nível traço normalmente requer GC-MS ou LC-MS/MS, com monitoramento seletivo de íons e padrões internos isotopicamente marcados.
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