N-nitroso-2 | 6-dicloro-purina é uma impureza nitrosada crítica observada em processos sintéticos envolvendo purinas halogenadas. Caracteriza-se por baixa solubilidade e estabilidade térmica limitada | exigindo métodos analíticos sensíveis para detecção | tipicamente HPLC acoplado a espectrometria de massas ou GC-MS após derivatização. Sua presença pode indicar reações secundárias de nitrosação e impactar a pureza e segurança do produto final | tornando essencial o desenvolvimento de perfis de impurezas | limites de especificação e estratégias de mitigação durante síntese e armazenamento. Estudos de degradação forense e validação analítica são recomendados para controle rigoroso conforme boas práticas de fabricação.
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