1500 ng/day is the U.S. FDA’s current Acceptable Intake (AI) limit for N-nitroso-diclofenac (NDSRI). Refer to the FDA nitrosamine page for the latest guidance.
Descrição
N-Nitroso Diclofenac (CAS 66505-80-4) é uma impureza relacionada a nitrosaminas derivada do diclofenaco, formalmente designada ácido 2-[2-(2,6-dicloro-N-nitrosoanilino)fenil]acético. Com fórmula molecular C14H10Cl2N2O3 e massa molecular de 325,15 g/mol, apresenta um motivo N-nitroso arilamina associado a preocupação genotóxica segundo os princípios da ICH M7. Sua formação pode ocorrer sob condições nitrosantes, por exposição a nitrito residual ou por vias de degradação oxidativa envolvendo a função amina secundária do composto parental. A elucidação estrutural e a quantificação em nível traço geralmente exigem LC-MS/MS, espectrometria de massas de alta resolução e, quando a volatilidade permite, confirmação por GC-MS, com atenção a supressão iônica e interferências isoméricas.
To provide the best experiences, we use technologies like cookies to store and/or access device information. Consenting to these technologies will allow us to process data such as browsing behavior or unique IDs on this site. Not consenting or withdrawing consent, may adversely affect certain features and functions.
Functional
Sempre ativo
The technical storage or access is strictly necessary for the legitimate purpose of enabling the use of a specific service explicitly requested by the subscriber or user, or for the sole purpose of carrying out the transmission of a communication over an electronic communications network.
Preferences
The technical storage or access is necessary for the legitimate purpose of storing preferences that are not requested by the subscriber or user.
Statistics
The technical storage or access that is used exclusively for statistical purposes.The technical storage or access that is used exclusively for anonymous statistical purposes. Without a subpoena, voluntary compliance on the part of your Internet Service Provider, or additional records from a third party, information stored or retrieved for this purpose alone cannot usually be used to identify you.
Marketing
The technical storage or access is required to create user profiles to send advertising, or to track the user on a website or across several websites for similar marketing purposes.
To provide the best experiences, we use technologies like cookies to store and/or access device information. Consenting to these technologies will allow us to process data such as browsing behavior or unique IDs on this site. Not consenting or withdrawing consent, may adversely affect certain features and functions.
Functional
Sempre ativo
The technical storage or access is strictly necessary for the legitimate purpose of enabling the use of a specific service explicitly requested by the subscriber or user, or for the sole purpose of carrying out the transmission of a communication over an electronic communications network.
Preferences
The technical storage or access is necessary for the legitimate purpose of storing preferences that are not requested by the subscriber or user.
Statistics
The technical storage or access that is used exclusively for statistical purposes.The technical storage or access that is used exclusively for anonymous statistical purposes. Without a subpoena, voluntary compliance on the part of your Internet Service Provider, or additional records from a third party, information stored or retrieved for this purpose alone cannot usually be used to identify you.
Marketing
The technical storage or access is required to create user profiles to send advertising, or to track the user on a website or across several websites for similar marketing purposes.
