N-Nitrosodiisobutylamine (NDIBA | CAS 997-95-5) é uma nitrosamina secundária que ocorre como impureza em processos químicos e farmacêuticos. Caracteriza-se por alta lipossolubilidade | relativa estabilidade e potencial genotóxico | exigindo monitoramento rigoroso e controles analíticos sensíveis. A detecção e quantificação habitualmente empregam GC-MS ou LC-MS/MS com extração por headspace | SPME ou QuEChERS | sendo necessário validar métodos com limites de quantificação baixos. Protocolos de controle de qualidade | avaliação de risco e medidas de mitigação contribuem para reduzir níveis residuais. NDIBA é também conhecida por sinônimos como N | N-Diisobutylnitrosamine e Bisisobutyl-N-nitrosoamine.
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