Norfloxacin EP Impurity F (Norfloxacin 6-Chloro Analog) | CAS 67681-84-9 | é uma impureza relacionada à norfloxacina caracterizada pela substituição do átomo de flúor pela presença de cloro na posição 6 do núcleo quinolínico. Sua ocorrência é observada como subproduto de síntese ou por reações de troca halogenada durante a produção e pode afetar o perfil de pureza do princípio ativo. Requer identificação e quantificação por técnicas analíticas como HPLC | LC-MS e RMN | além de determinação de limites específicos e estudo de estabilidade para atender requisitos de controle de qualidade farmacêutico e segurança do produto.
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