Phenylephrine Impurity G | identificado também como 3-hidroxiacetofenona (3-hydroxyacetophenone | m-acetylphenol) | é uma impureza comum em rotas sintéticas da fenilefrina que requer controle analítico rigoroso. Apresenta propriedades físico-químicas que alteram retenção cromatográfica e absorção UV | com padrões de fragmentação característicos detectáveis por LC-MS e GC-MS e confirmação estrutural por RMN. A sua presença pode impactar pureza do lote | estabilidade e conformidade regulatória | exigindo especificações claras | limites de aceitação e métodos validados de HPLC-UV e LC-MS/MS para quantificação. Dados analíticos e estratégias de purificação sustentam avaliações de risco e liberação de produto.
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