Phloroglucinol EP Impurity K (4-chlororesorcinol | CAS 95-88-5) é um contaminante clorado derivado do anel benzeno di-hidroxilado | caracterizado por maior lipofilicidade e acidez fenólica comparada ao phloroglucinol. Sua presença indica reações de cloração ou subprodutos de síntese. Analiticamente é detectável por HPLC reverso com detecção UV e por GC-MS após derivatização | exibindo tempo de retenção mais longo e padrão de fragmentação compatível com substituição por cloro. A determinação exige métodos validados para quantificação de níveis traço | avaliação de pureza e riscos de impurezas relacionadas | suportando conformidade com requisitos farmacopéicos.
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