Impureza (R)-1-(3 | 4-dihydroxyphenyl)-2-(methylamino)ethyl hydrogen sulfate (CAS 139183-81-6) é um derivado sulfato de catecolamina observado como subproduto no processo sintético e durante a degradação de adrenalina. De caráter polar e ionizável | apresenta alta solubilidade aquosa e comportamento de retenção reduzido em cromatografia reversa | exigindo métodos adequados de separação. A sua identificação e quantificação por HPLC acoplada a detector de massas ou LC-MS/MS é recomendada para assegurar especificidade e sensibilidade em níveis traço. Estudos de perfilagem forense | estabilidade e vias de sulfatação facilitam a interpretação da sua formação. Controle de qualidade deve incluir limites de aceitabilidade e procedimentos de investigação conforme guias regulatórios.
Referências
WebMD Editorial Contributors. “What to Know about an Adrenaline Rush.” WebMD, WebMD, 28 Apr. 2021, www.webmd.com/a-to-z-guides/what-to-know-adrenaline-rush#:~:text=Adrenalinealsoknownasepinephrine, giveyouanadrenalinerush..
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