(R)-3-(4-(5-bromo-2-chlorobenzyl)phenoxy)tetrahydrofuran (CAS 915095-90-8) é uma impureza identificada na síntese de Empagliflozin KSM. Trata-se de um isômero configuracional R com substituições bromo e cloro que pode afetar a pureza do intermediário e do produto final. A sua detecção e quantificação são realizadas por HPLC analítico e LC-MS | com necessidade de métodos quiralmente seletivos para separar enantiômeros. Estudos de estabilidade | perfil de degradados e limites de aceitação são essenciais para controle de qualidade e conformidade regulatória. Estratégias de purificação e otimização de etapa sintética minimizam seu nível | reduzindo riscos toxicológicos e variações no rendimento.
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