Telmisartan Benzimidazole Acid CAS 152628-03-0 é uma impureza processual crítica encontrada na síntese de telmisartana | caracterizada por uma estrutura benzimidazol com função ácido carboxílico que compromete pureza e estabilidade do lote. Sua presença indica reações secundárias incompletas ou degradação durante etapas de acoplamento e purificação. O monitoramento analítico por HPLC com detector UV e por LC-MS/MS permite quantificação sensível | e a validação de limites de identificação e quantificação assegura conformidade regulatória. Controles por otimização de condições reacionais e purificação cromatográfica reduzem risco toxicológico e perdas de rendimento.
Referências
Gosse, Philippe. “A Review of Telmisartan in the Treatment of Hypertension: Blood Pressure Control in the Early Morning Hours.†Vascular Health and Risk Management, vol. 2, no. 3, Aug. 2006, pp. 195–201, https://doi.org/10.2147/vhrm.2006.2.3.195. ‌
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