Informações adicionais sobre o Trans - Aminocarbinol
Fármaco de origem
Abacavir
Nome IUPAC
((1R, 4R)-4-aminocyclopent-2-en-1-yl)methanol
Sinônimos
N/A
Descrição
Trans-Aminocarbinol como impureza apresenta relevância analítica e regulatória devido à sua presença como isômero trans formado por reações secundárias durante rotas sintéticas. Caracteriza-se por maior polaridade e pontos de fusão e ebulição distintos do composto alvo | influenciando solubilidade e perfil de cristalização. Detectável por HPLC/UHPLC com padrões de referência | espectrometria de massas e RMN 1H/13C para confirmação estrutural. Avaliação de conteúdo e limiares de aceitação requer validação de método | amostragem representativa e estudos de estabilidade forçados para mapear vias de formação. Controle eficaz depende de otimização de condições reacionais | etapas de purificação cromatográfica e especificações de qualidade analítica.
Referências
Ann, H., Kim, K.-H., Choi, H.-Y., Chang, H.-H., Han, S. H., Kim, K.-H., … Kim, S.-W. (2017). Safety and Efficacy of Ziagen (Abacavir Sulfate) in HIV-Infected Korean Patients. Infection & Chemotherapy, 49(3), 205. https://doi.org/10.3947/ic.2017.49.3.205
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