Pramipexol Related Compound F (CAS 1246818-51-8; alternativer CAS 2166216-34-6) ist eine strukturell definierte schwefelhaltige Verunreinigung von Pramipexol mit der Summenformel C10H17N3OS und einer Molekülmasse von 227,33 g/mol. Ihr Auftreten ist typischerweise mit routenabhängigen synthetischen oder umwandlungsbedingten Verunreinigungen verbunden, die aus unvollständiger Cyclisierung, Seitenkettenmodifikation oder schwefelhaltigen Zwischenstufen entstehen, und nicht mit einem einfachen Abbauprodukt. Aufgrund der engen strukturellen Nähe zum Wirkscaffold kann die Kontrolle im Spurenbereich im Rahmen der Verunreinigungsqualifizierung und der ICH-M7-Bewertung relevant sein. Die eindeutige Charakterisierung erfordert üblicherweise LC-MS/MS, hochauflösende MS und chromatographische Trennung mittels LC-UV oder UPLC; ergänzend kann NMR zur Strukturabsicherung notwendig sein.
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