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136470-77-4Abacavir 5’-Phosphate

● Under Development

Katalog-Nr.::	VL760020
CAS-Nr.::	136470-77-4
Summenformel::	C14H19N6O4P
Molare Masse::	366.31 g/mol

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Zusätzliche Informationen zu CAS 136470-77-4

Parent drug

Abacavir

IUPAC-Name

(1s, 4r)- 4-[2-amino-6-(cyclopropylamino)-9h-purin-9-yl]-2-cyclopentene-1-methanoldihydrogen phosphate

Pharmakopöe-Synonyme

N/A

Other Synonyms

{(1S,4R)-4-[2-amino-6-(cyclopropylamino)-9H-purin-9-yl]cyclopent-2-en-1-yl}methyl dihydrogen phosphate; 2-cyclopentene-1-methanol; 4-(2-amino-6-(cyclopropylamino)-9H-purin-9-yl)-; dihydrogen phosphate (ester); (1S,4R)-abacavir 5′-monophosphate

Beschreibung

Abacavir 5’-Phosphate (CAS No: 136470-77-4) is a metabolite of Abacavir. It is used in the synthesis of guanine nucleotide analog and active antiviral compound carbovir 50-phosphate by the catalytic action of an unidentified cellular enzyme.

References

Schinkmanová, Markéta, et al. “N6-Methyl-AMP Aminohydrolase Activates N6-Substituted Purine Acyclic Nucleoside Phosphonates.” Biochemical Pharmacology, vol. 71, no. 9, Apr. 2006, pp. 1370–76, https://doi.org/10.1016/j.bcp.2006.01.013.