Atorvastatin Diketo Amide 2-Fluoro Analog
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Lagerstandorte

  • New Jersey, USA
  • Czech Republic, EU
  • Mumbai, India

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Dokumentation

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1797905-42-0Atorvastatin Diketo Amide 2-Fluoro Analog

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Katalog-Nr.::VE008630
CAS-Nr.::1797905-42-0
Summenformel::C26H24FNO3
Molare Masse::417.47 g/mol

Zusätzliche Informationen zu CAS 1797905-42-0

Parent drug

Atorvastatin

IUPAC-Name

2-(2-(2-Fluorophenyl)-2-oxo-1-phenylethyl)-4-methyl-3-oxo-N-phenyl Pentanamide

Synonyme

N/A

SMILES

CC(C)C(=O)C(C(C1=CC=CC=C1)C(=O)C2=CC=CC=C2F)C(=O)NC3=CC=CC=C3

Beschreibung

It is the oral antilipemic drug atorvastatin that reversibly inhibits HMG-CoA reductase. It raises plasma concentrations of HDL-C while decreasing levels of total cholesterol, low-density lipoprotein cholesterol (LDL-C), apolipoprotein B, non-high-density lipoprotein cholesterol (non-HDL-C), and triglyceride (TG). Atherosclerosis and cardiovascular disease are related to high LDL-C, low HDL-C, and high TG concentrations in the plasma. A major indicator of coronary artery disease is the ratio of total cholesterol to HDL-C, and greater ratios are linked to a higher risk of the condition. Lower cardiovascular risk is linked to higher HDL-C levels. A statin like atorvastatin lowers the risk of cardiovascular morbidity and death by lowering LDL-C and TG and raising HDL-C.

References

McIver, Lindsey A., and Momin S. Siddique. “Atorvastatin.” Nih.gov, StatPearls Publishing, 15 May 2022, www.ncbi.nlm.nih.gov/books/NBK430779/.

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