Cabozantinib Impurity 1

● Under Development

Catalogue No.:	VE0025332
CAS No.:	N/A
Mol. Formula:	C56H49F2N6O10
Mol. Weight:	1004.02 g/mol

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Additional information on Cabozantinib Impurity 1

Parent drug

Cabozantinib

IUPAC Name

1-(4-((4-((6,7-dimethoxyquinolin-4-yl)oxy)phenyl)amino)-3-((4-fluorophenyl)carbamoyl)-4-oxobutyl)-4-(4-(1-((4-fluorophenyl)carbamoyl)cyclopropanecarboxamido)phenoxy)-6,7-dimethoxyquinolin-1-ium

Pharmacopeial Synonyms

N/A

Synonyms

N/A

Smiles

FC1=CC=C(NC(C(CC[N+]2=C(C=C(OC)C(OC)=C3)C3=C(OC4=CC=C(NC(C5(CC5)C(NC6=CC=C(F)C=C6)=O)=O)C=C4)C=C2)C(NC7=CC=C(OC8=CC=NC9=C8C=C(OC)C(OC)=C9)C=C7)=O)=O)C=C1

InChI

InChI=1S/C56H48F2N6O10/c1-69-48-29-42-44(31-50(48)71-3)59-26-21-46(42)73-39-17-13-36(14-18-39)61-53(66)41(52(65)60-35-9-5-33(57)6-10-35)22-27-64-28-23-47(43-30-49(70-2)51(72-4)32-45(43)64)74-40-19-15-38(16-20-40)63-55(68)56(24-25-56)54(67)62-37-11-7-34(58)8-12-37/h5-21,23,26,28-32,41H,22,24-25,27H2,1-4H3,(H3-,60,61,62,63,65,66,67,68)/p+1

Description

Cabozantinib Impurity 1 is a defined process-related related substance associated with the multikinase inhibitor cabozantinib, represented by molecular formula C56H49F2N6O10 and molecular weight 1004.02 g/mol. Its structure indicates a highly substituted, lipophilic aromatic scaffold bearing multiple heteroatoms and carbonyl functionalities, consistent with a late-stage synthetic byproduct or oxidative coupling derivative rather than a simple degradant. Owing to its complexity and low expected abundance, characterization typically requires LC-MS/MS, high-resolution mass spectrometry, and orthogonal LC-UV or NMR confirmation. In regulatory impurity profiling, such a species is evaluated for structural assignment, formation pathway, and potential toxicological relevance under impurity control principles.