Spiro Almotriptan, also known as 1,2-Dihydro-1′-methyl-5-((1-pyrrolidinylsulfonyl)methyl)spiro(3H-indole-3,3′-pyrrolidin)-2-ol; Spiro(3H-indole-3,3′-pyrrolidin)-2-ol, 1,2-dihydro-1′-methyl-5-((1-pyrrolidinylsulfonyl)methyl)-, is a highly characterized reference material. It fully complies with stringent regulatory standards, including those set by USP, EMA, JP, and BP. This product is essential for use in Abbreviated New Drug Applications (ANDA), New Drug Applications (NDA), and the commercial production of Almotriptan. Moreover, it comes with a detailed Structure Elucidation Report (SER), ensuring its accuracy and reliability for a wide range of analytical applications. Spiro Almotriptan or 1′-Methyl-5-((pyrrolidin-1-ylsulfonyl)methyl)spiro[indoline-3,3′-pyrrolidin]-2-ol, is a potent and selective 5-HT(1B/1D) receptor agonist,oral administration is approximately 70%, used in the treatment of migraine headaches.
References
Sandrini, Giorgio, et al. “Almotriptan in the Treatment of Migraine.†Neuropsychiatric Disease and Treatment, vol. 3, no. 6, 1 Dec. 2007, pp. 799–809, www.ncbi.nlm.nih.gov/pmc/articles/PMC2656322/.
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