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1036959-27-9Vildagliptin (2R)-Isomer
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| Catalogue No.: | VL3490001 |
|---|---|
| CAS No.: | 1036959-27-9 |
| Mol. Formula: | C17H25N3O2 |
| Mol. Weight: | 303.4 g/mol |
Additional information on CAS 1036959-27-9
Parent drug
ViladagliptinIUPAC Name
(2R)-1-[2-[(3-Hydroxytricyclo[3.3.1.13,7]dec-1-yl)amino]acetyl]-2-pyrrolidine carbonitrileSynonyms
N/ADescription
Vildagliptin (2R)-Isomer, CAS 1036959-27-9, is a stereochemical impurity of the dipeptidyl peptidase-4 inhibitor vildagliptin arising from epimeric misselection or incomplete stereocontrol during synthesis. With molecular formula C17H25N3O2 and molecular weight 303.4 g/mol, it is not a structural analog but a configurational isomer that may alter pharmacological and impurity profiles through differences in binding geometry and chromatographic behavior. Quantitation typically requires chiral LC with UV or MS detection, and confirmation by LC-MS/MS, NMR, or, where needed, high-resolution mass spectrometry. It is evaluated as a process-related impurity under pharmaceutical impurity control concepts rather than as a reactive genotoxic species.References
By Chantal Mathieu Container: Vascular Health and Risk Management Year: 2008 Volume: Volume 4 DOI: 10.2147/vhrm.s3005 URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2663430/Request a Quote
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