Cabozantinib-Impurity 20, CAS 13425-93-9, ist eine aromatische heterocyclische Verbindung mit der Summenformel C11H11NO3 und einer Molmasse von 205,21 g/mol. Die empirische Zusammensetzung entspricht einem Pyridincarbonsäure-Derivat und weist damit auf ein kleines, polares Fragment im Rahmen des prozessbezogenen Verunreinigungsprofils hin, nicht auf eine Nitrosamin-Struktur. Solche Spezies können durch unvollständige Ringschlussreaktionen, Oxidation oder hydrolytische Nebenreaktionen bei der Zwischenstufenherstellung entstehen. Aufgrund der geringen Gehalte und der Nähe zu Vorläuferstrukturen werden zur Identifizierung typischerweise LC-MS/MS, hochauflösende LC-MS sowie ergänzend NMR eingesetzt. Regulatorisch wird sie als verfahrensspezifische Verunreinigung nach ICH Q3A/Q3B bewertet.
To provide the best experiences, we use technologies like cookies to store and/or access device information. Consenting to these technologies will allow us to process data such as browsing behavior or unique IDs on this site. Not consenting or withdrawing consent, may adversely affect certain features and functions.
Functional
Immer aktiv
The technical storage or access is strictly necessary for the legitimate purpose of enabling the use of a specific service explicitly requested by the subscriber or user, or for the sole purpose of carrying out the transmission of a communication over an electronic communications network.
Preferences
The technical storage or access is necessary for the legitimate purpose of storing preferences that are not requested by the subscriber or user.
Statistics
The technical storage or access that is used exclusively for statistical purposes.The technical storage or access that is used exclusively for anonymous statistical purposes. Without a subpoena, voluntary compliance on the part of your Internet Service Provider, or additional records from a third party, information stored or retrieved for this purpose alone cannot usually be used to identify you.
Marketing
The technical storage or access is required to create user profiles to send advertising, or to track the user on a website or across several websites for similar marketing purposes.
To provide the best experiences, we use technologies like cookies to store and/or access device information. Consenting to these technologies will allow us to process data such as browsing behavior or unique IDs on this site. Not consenting or withdrawing consent, may adversely affect certain features and functions.
Functional
Immer aktiv
The technical storage or access is strictly necessary for the legitimate purpose of enabling the use of a specific service explicitly requested by the subscriber or user, or for the sole purpose of carrying out the transmission of a communication over an electronic communications network.
Preferences
The technical storage or access is necessary for the legitimate purpose of storing preferences that are not requested by the subscriber or user.
Statistics
The technical storage or access that is used exclusively for statistical purposes.The technical storage or access that is used exclusively for anonymous statistical purposes. Without a subpoena, voluntary compliance on the part of your Internet Service Provider, or additional records from a third party, information stored or retrieved for this purpose alone cannot usually be used to identify you.
Marketing
The technical storage or access is required to create user profiles to send advertising, or to track the user on a website or across several websites for similar marketing purposes.
