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1309457-19-92-Hydroxyalmotriptan

● Under Development

Katalog-Nr.::	VE0021434
CAS-Nr.::	1309457-19-9
Summenformel::	C17H25N3O3S
Molare Masse::	351.47 g/mol

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Zusätzliche Informationen zu CAS 1309457-19-9

Parent drug

Almotriptan

IUPAC-Name

3-(2-(Dimethylamino)ethyl)-5-((pyrrolidin-1-ylsulfonyl)methyl)-1H-indol-2-ol

Pharmakopöe-Synonyme

N/A

Other Synonyms

N/A

SMILES

OC(N1)=C(CCN(C)C)C2=C1C=CC(CS(=O)(N3CCCC3)=O)=C2

Beschreibung

2-Hydroxyalmotriptan (CAS 1309457-19-9) is a process-related impurity observed during almotriptan synthesis, characterized by a hydroxy substitution on the indole-propyl side chain. Analytical characterization includes HPLC retention behavior, LC-MS accurate mass confirmation, and NMR for structural assignment, with UV chromophores affecting detection sensitivity. It can arise from incomplete deprotection or oxidative hydroxylation pathways and may impact assay, stability, and impurity profiling if not controlled. Recommended control strategies include validated HPLC methods, reference standard qualification, ICH Q3A/B thresholds, and targeted purification to ensure batch consistency and regulatory compliance.