Aliskiren Carboxylic Acid Impurity (CAS No: 173400-13-0) is a metabolite formed during the industrial synthesis of Aliskiren that is applied during the treatment of hypertension and serves by selectively inhibiting renin which is an enzyme effective in the conversion of angiotensinogen to angiotensin-I.
References
Kushwah, Bhoopendra Singh, et al. “Characterization of Solution Stress Degradation Products of Aliskiren and Prediction of Their Physicochemical and ADMET Properties.â€Â European Journal of Pharmaceutical Sciences, vol. 121, Aug. 2018, pp. 139–54, https://doi.org/10.1016/j.ejps.2018.05.021.
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