| Parent Drug Name | Name of Impurity | Catalogue No. | |
|---|---|---|---|
| Aliskiren | Aliskiren 4-O-Desmethyl Impurity | VL5780004 | View CAS 949925-74-0 |
| Aliskiren | Aliskiren 8-Hydroxy Impurity | VL5780002 | View CAS 1438401-04-7 |
| Aliskiren | Aliskiren Acid Impurity Sodium Salt | VE0012134 | View |
| Aliskiren | Aliskiren Amino Lactone Impurity | VL5780007 | View |
| Aliskiren | Aliskiren Carboxylic Acid Impurity | VL5780008 | View CAS 173400-13-0 |
| Aliskiren | Aliskiren Hemifumarate (RRRS Isomer) Impurity | VL5780009 | View |
| Aliskiren | Aliskiren Hemifumarate (SSSR Isomer) Impurity | VL5780010 | View |
| Aliskiren | Aliskiren Hemifumarate Enantiomer (RRRR Isomer) Impurity | VL5780011 | View |
| Aliskiren | Aliskiren N-Benzyloxycarbonyl Impurity | VL5780015 | View CAS 1236549-06-6 |
| Aliskiren | Aliskiren N-Maleic Acid Impurity | VL5780003 | View |
| Aliskiren | Aliskiren O-Desmethoxypropyl Impurity | VL5780016 | View CAS 949925-77-3 |
| Aliskiren | Aliskiren-D6 Hemifumarate | DVE00134 | View |
| Aliskiren | Desmethoxy Aliskiren Impurity | VL5780012 | View |
| Aliskiren | N-Boc Aliskiren | VL5780006 | View CAS 173338-07-3 |
Aliskiren Related Compound
The burden on the heart and arteries is increased by high blood pressure.
References
- “Aliskiren: MedlinePlus Drug Information.” Medlineplus.gov, 2021, medlineplus.gov/druginfo/meds/a607039.html#:~:text=Aliskiren%20is%20in%20a%20class,can%20pump%20blood%20more%20efficiently. Accessed 7 Feb. 2023.
- “Renin Inhibitors (Aliskiren).” Straighthealthcare.com, 2013, www.straighthealthcare.com/renin-inhibitors.html#:~:text=Medications%20that%20can%20raise%20potassium,medications%2C%20the%20risk%20is%20increased. Accessed 7 Feb. 2023.
- Virdis, Agostino, et al. “Effect of Aliskiren Treatment on Endothelium-Dependent Vasodilation and Aortic Stiffness in Essential Hypertensive Patients.” European Heart Journal, vol. 33, no. 12, Mar. 2012, pp. 1530–38, https://doi.org/10.1093/eurheartj/ehs057. Accessed 7 Feb. 2023.
FAQ’s
Aliskiren belongs to what drug class?
Aliskiren belongs to the group of drugs known as direct renin inhibitors.
Does aliskiren cause an increase in potassium?
Aliskiren may lead to hyperkalemia by increasing potassium levels. The danger rises when used with other potassium-raising drugs.
Is aliskiren a vasodilator?
The inhibitory impact of l-NMMA on acetylcholine was restored by aliskiren, which also raised the vasodilation to acetylcholine. After receiving aliskiren, ascorbic acid, which at baseline potentiated the response to acetylcholine, no longer enhanced endothelium-dependent relaxation.
