Aliskiren Impurities

Aliskiren is used to treat high blood pressure either alone or in combination with other medications (hypertension).

veeprho banner
Parent Drug Name Name of Impurity Catalogue No.
Aliskiren Aliskiren 4-O-Desmethyl Impurity VL5780004View CAS 949925-74-0
Aliskiren Aliskiren 8-Hydroxy Impurity VL5780002View CAS 1438401-04-7
Aliskiren Aliskiren Acid Impurity Sodium Salt VE0012134View
Aliskiren Aliskiren Amino Lactone Impurity VL5780007View
Aliskiren Aliskiren Carboxylic Acid Impurity VL5780008View CAS 173400-13-0
Aliskiren Aliskiren Hemifumarate (RRRS Isomer) Impurity VL5780009View
Aliskiren Aliskiren Hemifumarate (SSSR Isomer) Impurity VL5780010View
Aliskiren Aliskiren Hemifumarate Enantiomer (RRRR Isomer) Impurity VL5780011View
Aliskiren Aliskiren N-Benzyloxycarbonyl Impurity VL5780015View CAS 1236549-06-6
Aliskiren Aliskiren N-Maleic Acid Impurity VL5780003View
Aliskiren Aliskiren O-Desmethoxypropyl Impurity VL5780016View CAS 949925-77-3
Aliskiren Aliskiren-D6 Hemifumarate DVE00134View
Aliskiren Desmethoxy Aliskiren Impurity VL5780012View
Aliskiren N-Boc Aliskiren VL5780006View CAS 173338-07-3

Aliskiren Related Compound

The burden on the heart and arteries is increased by high blood pressure.

References

  • “Aliskiren: MedlinePlus Drug Information.” Medlineplus.gov, 2021, medlineplus.gov/druginfo/meds/a607039.html#:~:text=Aliskiren%20is%20in%20a%20class,can%20pump%20blood%20more%20efficiently. Accessed 7 Feb. 2023.
  • “Renin Inhibitors (Aliskiren).” Straighthealthcare.com, 2013, www.straighthealthcare.com/renin-inhibitors.html#:~:text=Medications%20that%20can%20raise%20potassium,medications%2C%20the%20risk%20is%20increased. Accessed 7 Feb. 2023. ‌
  • Virdis, Agostino, et al. “Effect of Aliskiren Treatment on Endothelium-Dependent Vasodilation and Aortic Stiffness in Essential Hypertensive Patients.” European Heart Journal, vol. 33, no. 12, Mar. 2012, pp. 1530–38, https://doi.org/10.1093/eurheartj/ehs057. Accessed 7 Feb. 2023. ‌

FAQ’s

Aliskiren belongs to what drug class?

Aliskiren belongs to the group of drugs known as direct renin inhibitors.

Does aliskiren cause an increase in potassium?

Aliskiren may lead to hyperkalemia by increasing potassium levels. The danger rises when used with other potassium-raising drugs.

Is aliskiren a vasodilator?

The inhibitory impact of l-NMMA on acetylcholine was restored by aliskiren, which also raised the vasodilation to acetylcholine. After receiving aliskiren, ascorbic acid, which at baseline potentiated the response to acetylcholine, no longer enhanced endothelium-dependent relaxation.

[rfq_list]

Request a quote

1236549-06-6: Aliskiren N-Benzyloxycarbonyl Impurity

1236549-06-6: Aliskiren N-Benzyloxycarbonyl Impurity
Catalogue No.

VL5780015

CAS No.

1236549-06-6

Molecular Formula

C38H59N3O8

Molecular Weight

685.89 g/mol

Parent drug

Aliskiren

IUPAC Name

(αS, γS, δS, zS)-δ-(Benzyloxycarbonyl)amino-N-(3-amino-2, 2-dimethyl-3-oxopropyl)-γ-hydroxy-4-methoxy-3-(3-methoxypropoxy)-α, z-bis(1-methylethyl)benzeneoctanamide

Synonyms

N/A

References

Frampton, James E., and Monique P. Curran. “Aliskiren.” Drugs, vol. 67, no. 12, 2007, pp. 1767–92, https://doi.org/10.2165/00003495-200767120-00008.

Status

In-stock

ListName

Aliskiren N-Benzyloxycarbonyl Impurity

Exclusively Supplied by Veeprho

Exclusively Supplied by Veeprho

"*" indicates required fields

Hidden
Products quotation
Name
Url
 
Hidden