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81353-09-5Diltiazem EP Impurity G

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Katalog-Nr.::	VL1080004
CAS-Nr.::	81353-09-5
Summenformel::	C19H22N2O3S
Molare Masse::	358.45 g/mol

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Zusätzliche Informationen zu CAS 81353-09-5

Parent drug

Diltiazem

IUPAC-Name

3-Hydroxy-2-(4-methoxy-phenyl)-5-(2-methylamino-ethyl)-2, 3-dihydro-5H-benzo[b][1, 4]thiazepin-4-one

Synonyme

Diltiazem Related Compound G; O-Desacetyl-N-desmethyl Diltiazem

SMILES

CNCCN1C2=CC=CC=C2SC(C(C1=O)O)C3=CC=C(C=C3)OC

Beschreibung

Also known as Diltiazem Related Compound G, O-Desacetyl-N-desmethyl Diltiazem or 3-Hydroxy-2-(4-methoxy-phenyl)-5-(2-methylamino-ethyl)-2,3-dihydro-5H-benzo[b][1,4]thiazepin-4-one is a metabolite of Diltiazem which is a calcium antagonist. Diltiazem is known to employ complex cardioprotective effects which have been of benefits post intracoronary administration to patients going through coronary angiography and bypass procedures.

References

MIYAZAKI, MICHIHIKO, et al. “Synthesis of the Metabolites and Related Compounds of Diltiazem.” Chemical and Pharmaceutical Bulletin, vol. 26, no. 9, 1978, pp. 2889–93, https://doi.org/10.1248/cpb.26.2889.?Buckley, Micaela M. -T ., et al. “Diltiazem.” Drugs, vol. 39, no. 5, May 1990, pp. 757–806, https://doi.org/10.2165/00003495-199039050-00009.?