Diltiazem Related Compound G; O-Desacetyl-N-desmethyl Diltiazem
SMILES
CNCCN1C2=CC=CC=C2SC(C(C1=O)O)C3=CC=C(C=C3)OC
説明
Also known as Diltiazem Related Compound G, O-Desacetyl-N-desmethyl Diltiazem or 3-Hydroxy-2-(4-methoxy-phenyl)-5-(2-methylamino-ethyl)-2,3-dihydro-5H-benzo[b][1,4]thiazepin-4-one is a metabolite of Diltiazem which is a calcium antagonist. Diltiazem is known to employ complex cardioprotective effects which have been of benefits post intracoronary administration to patients going through coronary angiography and bypass procedures.
References
MIYAZAKI, MICHIHIKO, et al. “Synthesis of the Metabolites and Related Compounds of Diltiazem.” Chemical and Pharmaceutical Bulletin, vol. 26, no. 9, 1978, pp. 2889–93, https://doi.org/10.1248/cpb.26.2889.?Buckley, Micaela M. -T ., et al. “Diltiazem.” Drugs, vol. 39, no. 5, May 1990, pp. 757–806, https://doi.org/10.2165/00003495-199039050-00009.?
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