Levetiracetam Related Compound B, auch als L-2-Aminobutanamid oder Levetiracetam EP Impurity G bezeichnet, ist die freie Base eines Aminamids mit der CAS-Nummer 7324-11-0. Mit der Summenformel C4H10N2O und einer Molekülmasse von 102,14 g/mol handelt es sich um einen kleinen, stark polaren, synthetischen Zwischenstoff oder prozessbezogenen Nebenbestandteil, der aus unvollständiger Cyclisierung oder Amidierungsreaktionen bei der Herstellung von Levetiracetam hervorgehen kann. Als nicht chromophorer, basischer Verunreinigungsstoff erfordert seine Bestimmung häufig LC-MS/MS oder derivatisierte GC-MS, oft in Kombination mit HILIC- oder Ion-Pair-Chromatographie zur ausreichenden Trennung. Die Identifizierung ist im Rahmen pharmakopöischer und ICH-basierten Verunreinigungsprofile relevant.
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