Levetiracetam Related Compound B, also identified as L-2-aminobutanamide or Levetiracetam EP Impurity G, is the free-base amino amide impurity corresponding to CAS 7324-11-0. With molecular formula C4H10N2O and molecular weight 102.14 g/mol, it represents a small, polar synthetic intermediate or process-related byproduct arising from incomplete cyclization or amidation steps in levetiracetam manufacture. As a non-chromophoric basic impurity, its determination commonly requires LC-MS/MS or derivatized GC-MS, often coupled with HILIC or ion-pair chromatography for resolution. Its structural assignment is relevant to impurity profiling under pharmacopeial and ICH impurity control frameworks.
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