100 % Datengenauigkeit
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0 % Toleranz bei der Produktqualität
Lagerstandorte
- New Jersey, USA
- Czech Republic, EU
- Mumbai, India
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Dokumentation
Enthält: HPLC, MASS/LC-MS, 1H-NMR, FT-IR, Gehalt, Structure Elucidation Report (SER) sowie zusätzliche analytische Daten je nach Produkt.
854898-48-9Rosuvastatin (6R)-Isomer Sodium Salt
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| Katalog-Nr.:: | VE008979 |
|---|---|
| CAS-Nr.:: | 854898-48-9 |
| Summenformel:: | C22H27FN3NaO6S |
| Molare Masse:: | 503.52 g/mol |
Zusätzliche Informationen zu CAS 854898-48-9
Parent drug
RosuvastatinIUPAC-Name
(3R, 5S)-5-[(6R)-8-Fluoro-4-isopropyl-2-(N-methylmethylsulfonamido)-5, 6-dihydrobenzo[h]quinazolin-6-yl]-3, 5-dihydroxypentanoic acid sodium saltSynonyme
N/ABeschreibung
It is an HMG-CoA reductase inhibitor of newer generation, rosuvastatin has certain distinct pharmacologic and pharmacokinetic characteristics. It has significant LDL-C lowering potential, the minimal potential for CYP3A4 interactions, and low extrahepatic tissue penetration. A completely synthesized HMG-CoA reductase inhibitor is rosuvastatin. Other HMG-CoA reductase inhibitors are either synthetically made from heptanoic acid or naturally produced from mevalonic acid (lovastatin, simvastatin, and pravastatin) (atorvastatin, fluvastatin). A novel class of 3, 5-dihydroxy-heptanoate and N-methane sulfonyl pyrrole-substituted methane sulphonamide pyrimidines include rosuvastatin. Including stable polar methane-sulphonamide group results in low lipophilicity and improved ionic interaction with the HMG-CoA reductase enzyme, enhancing its binding affinity to this enzyme even if the characteristic statin pharmacophore is comparable to that of other statins.References
Luvai, Ahai, et al. “Rosuvastatin: A Review of the Pharmacology and Clinical Effectiveness in Cardiovascular Disease.†Clinical Medicine Insights: Cardiology, vol. 6, Jan. 2012, p. CMC.S4324, https://doi.org/10.4137/cmc.s4324. ‌Angebot anfordern
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