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포함 사항: HPLC, MASS/LC-MS, 1H NMR, FT-IR, 함량, 구조 규명 보고서(SER), 그리고 제품에 따라 추가 분석 데이터가 제공됩니다.

854898-48-9Rosuvastatin (6R)-Isomer Sodium Salt

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카탈로그 번호:	VE008979
CAS 번호:	854898-48-9
분자식:	C22H27FN3NaO6S
분자량:	503.52 g/mol

견적 요청

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모약물

Rosuvastatin

IUPAC명

(3R, 5S)-5-[(6R)-8-Fluoro-4-isopropyl-2-(N-methylmethylsulfonamido)-5, 6-dihydrobenzo[h]quinazolin-6-yl]-3, 5-dihydroxypentanoic acid sodium salt

동의어

N/A

설명

It is an HMG-CoA reductase inhibitor of newer generation, rosuvastatin has certain distinct pharmacologic and pharmacokinetic characteristics. It has significant LDL-C lowering potential, the minimal potential for CYP3A4 interactions, and low extrahepatic tissue penetration. A completely synthesized HMG-CoA reductase inhibitor is rosuvastatin. Other HMG-CoA reductase inhibitors are either synthetically made from heptanoic acid or naturally produced from mevalonic acid (lovastatin, simvastatin, and pravastatin) (atorvastatin, fluvastatin). A novel class of 3, 5-dihydroxy-heptanoate and N-methane sulfonyl pyrrole-substituted methane sulphonamide pyrimidines include rosuvastatin. Including stable polar methane-sulphonamide group results in low lipophilicity and improved ionic interaction with the HMG-CoA reductase enzyme, enhancing its binding affinity to this enzyme even if the characteristic statin pharmacophore is comparable to that of other statins.

References

Luvai, Ahai, et al. â€œRosuvastatin: A Review of the Pharmacology and Clinical Effectiveness in Cardiovascular Disease.â€ Clinical Medicine Insights: Cardiology, vol. 6, Jan. 2012, p. CMC.S4324, https://doi.org/10.4137/cmc.s4324. â€Œ