Lagerstandorte

New Jersey, USA
Czech Republic, EU
Mumbai, India

* Vorbehaltlich Verfügbarkeit

Dokumentation

MSDS herunterladen

Beispiel-COA herunterladen

Enthält: HPLC, MASS/LC-MS, 1H-NMR, FT-IR, Gehalt, Structure Elucidation Report (SER) sowie zusätzliche analytische Daten je nach Produkt.

1008-35-1Tetrahydrobiopterin Impurity 2

● Auf Lager

Katalog-Nr.::	VE0026126
CAS-Nr.::	1008-35-1
Summenformel::	C6H9N5O
Molare Masse::	167.17 g/mol

Angebot anfordern

Zur RFQ-Liste hinzufügen

Zusätzliche Informationen zu CAS 1008-35-1

Parent drug

Sapropterin

IUPAC-Name

2-amino-5,6,7,8-tetrahydropteridin-4-ol

SMILES

NC1=NC(O)=C2NCCNC2=N1

InChI

InChI=1S/C6H9N5O/c7-6-10-4-3(5(12)11-6)8-1-2-9-4/h8H,1-2H2,(H4,7,9,10,11,12)

Beschreibung

Tetrahydrobiopterin Impurity 2 (CAS 1008-35-1) is a process-related and degradation impurity encountered during synthesis and storage of tetrahydrobiopterin. It exhibits distinct chromatographic retention and a characteristic LC-MS fragmentation pattern that facilitates targeted trace-level quantification. Structural elucidation by NMR confirms substitution patterns responsible for altered redox behavior, increasing susceptibility to oxidative conversion under acidic or basic conditions. Control strategies include solvent selection, pH optimization, incorporation of antioxidants, and in-process purification to limit formation. Routine HPLC and LC-MS monitoring, method validation for sensitivity, and specification setting are recommended to ensure impurity qualification per regulatory expectations and to maintain product quality.