156547-62-5Salbutamol EP Impurity J (Free Base)

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Catalogue No.:	VE009765
CAS No.:	156547-62-5
Mol. Formula:	C13H19NO3
Mol. Weight:	237.29 g/mol

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Additional information on CAS 156547-62-5

Parent drug

Salbutamol

IUPAC Name

2-(tert-Butylamino)-1-[4-hydroxy-3-(hydroxymethyl)phenyl]ethanone

Pharmacopoeial Synonyms

Salbutamol BP Impurity J / Albuterol Related Compound B

Other Synonyms

Salbutamone; Salbutamol ketone impurity ;Albuterone;2-((1,1-Dimethylethyl)amino)-1-(4-hydroxy-3-(hydroxymethyl)phenyl)ethanone;2-(tert-Butylamino)-1-[4-hydroxy-3-(hydroxymethyl)phenyl]ethan-1-one

Smile

OCC1=CC(C(CNC(C)(C)C)=O)=CC=C1O

InChI

InChI=1S/C13H19NO3/c1-13(2,3)14-7-12(17)9-4-5-11(16)10(6-9)8-15/h4-6,14-16H,7-8H2,1-3H3

Description

Also known as Salbutamol ketone impurity or Salbutamol BP Impurity J or Salbutamone (Free Base) is an impurity present in Salbutamol, Salbutamol is a short-acting, selective beta2-adrenergic receptor agonist, activation of beta2-adrenergic receptors on airway smooth muscle leads to the activation of adenyl cyclase and an increase in the intracellular concentration of cyclic-3′,5′-adenosine monophosphate. This increase of cyclic AMP leads to the activation of protein kinase A, which inhibits the phosphorylation of myosin and lowers intracellular ionic calcium concentrations resulting in relaxation. Salbutamol relaxes the smooth muscles of all airways from the trachea to the terminal bronchioles Salbutamol acts as a functional antagonist to relax the airway irrespective of the spasmogen involved protecting against all bronchoconstrictor challenges.

References

‌Ullmann, N., Caggiano, S., & Cutrera, R. (2015). Salbutamol and around. Italian Journal of Pediatrics, 41(Suppl 2), A74. https://doi.org/10.1186/1824-7288-41-s2-a74