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156547-62-5Salbutamol EP Impurity J (Free Base)
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| Catalogue No.: | VE009765 |
|---|---|
| CAS No.: | 156547-62-5 |
| Mol. Formula: | C13H19NO3 |
| Mol. Weight: | 237.29 g/mol |
Additional information on CAS 156547-62-5
Parent drug
SalbutamolIUPAC Name
2-(tert-Butylamino)-1-[4-hydroxy-3-(hydroxymethyl)phenyl]ethanonePharmacopoeial Synonyms
Salbutamol BP Impurity J / Albuterol Related Compound BOther Synonyms
Salbutamone; Salbutamol ketone impurity ;Albuterone;2-((1,1-Dimethylethyl)amino)-1-(4-hydroxy-3-(hydroxymethyl)phenyl)ethanone;2-(tert-Butylamino)-1-[4-hydroxy-3-(hydroxymethyl)phenyl]ethan-1-oneSmile
OCC1=CC(C(CNC(C)(C)C)=O)=CC=C1OInChI
InChI=1S/C13H19NO3/c1-13(2,3)14-7-12(17)9-4-5-11(16)10(6-9)8-15/h4-6,14-16H,7-8H2,1-3H3Description
Salbutamol EP Impurity J, also designated salbutamol ketone impurity, salbutamone, and albuterol related compound B (free base), is a non-genotoxic process and degradation impurity of the phenethanolamine β2-agonist scaffold. It is structurally defined by oxidation of the secondary alcohol side chain to the corresponding ketone, retaining the aminoalcohol framework as C13H19NO3, molecular weight 237.29 g/mol, CAS 156547-62-5. In regulatory impurity profiling, its low-level measurement commonly requires LC-MS/MS with orthogonal confirmation by HPLC-UV or NMR, and in complex matrices derivatization-assisted GC-MS may be applied to resolve closely related catecholamine analogues.References
Ullmann, N., Caggiano, S., & Cutrera, R. (2015). Salbutamol and around. Italian Journal of Pediatrics, 41(Suppl 2), A74. https://doi.org/10.1186/1824-7288-41-s2-a74Request a Quote
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