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0 % Toleranz bei der Produktqualität
Lagerstandorte
- New Jersey, USA
- Czech Republic, EU
- Mumbai, India
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Dokumentation
Enthält: HPLC, MASS/LC-MS, 1H-NMR, FT-IR, Gehalt, Structure Elucidation Report (SER) sowie zusätzliche analytische Daten je nach Produkt.
156547-62-5Salbutamol EP Impurity J (Free Base)
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| Katalog-Nr.:: | VE009765 |
|---|---|
| CAS-Nr.:: | 156547-62-5 |
| Summenformel:: | C13H19NO3 |
| Molare Masse:: | 237.29 g/mol |
Zusätzliche Informationen zu CAS 156547-62-5
Parent drug
SalbutamolIUPAC-Name
2-(tert-Butylamino)-1-[4-hydroxy-3-(hydroxymethyl)phenyl]ethanonePharmakopöe-Synonyme
Salbutamol BP Impurity J / Albuterol Related Compound BOther Synonyms
Salbutamone; Salbutamol ketone impurity ;Albuterone;2-((1,1-Dimethylethyl)amino)-1-(4-hydroxy-3-(hydroxymethyl)phenyl)ethanone;2-(tert-Butylamino)-1-[4-hydroxy-3-(hydroxymethyl)phenyl]ethan-1-oneSmile
OCC1=CC(C(CNC(C)(C)C)=O)=CC=C1OInChI
InChI=1S/C13H19NO3/c1-13(2,3)14-7-12(17)9-4-5-11(16)10(6-9)8-15/h4-6,14-16H,7-8H2,1-3H3Beschreibung
Also known as Salbutamol ketone impurity or Salbutamol BP Impurity J or Salbutamone (Free Base) is an impurity present in Salbutamol, Salbutamol is a short-acting, selective beta2-adrenergic receptor agonist, activation of beta2-adrenergic receptors on airway smooth muscle leads to the activation of adenyl cyclase and an increase in the intracellular concentration of cyclic-3′,5′-adenosine monophosphate. This increase of cyclic AMP leads to the activation of protein kinase A, which inhibits the phosphorylation of myosin and lowers intracellular ionic calcium concentrations resulting in relaxation. Salbutamol relaxes the smooth muscles of all airways from the trachea to the terminal bronchioles Salbutamol acts as a functional antagonist to relax the airway irrespective of the spasmogen involved protecting against all bronchoconstrictor challenges.References
Ullmann, N., Caggiano, S., & Cutrera, R. (2015). Salbutamol and around. Italian Journal of Pediatrics, 41(Suppl 2), A74. https://doi.org/10.1186/1824-7288-41-s2-a74Angebot anfordern
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