(S)-Phthaloylalanine Disodium Salt is an ionic phthalimide-derived amino acid impurity associated with protection and deprotection chemistry in peptide or amino acid synthesis, where incomplete hydrolysis or rearrangement can leave a persistent anionic residue. Its molecular formula, C11H9NO5.2Na, corresponds to a molecular weight of 235.20 plus 2 x 22.99 g/mol, reflecting the disodium salt form. The compound is typically examined by LC-MS/MS for identity and trace quantification, with ion chromatography or HILIC methods supporting separation from related aromatic impurities. As a nonvolatile, polar species, it is unsuitable for GC-MS without derivatization.
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