Gefitinib Impurity V (CAS No: 367-21-5) or 4-Fluoro-3-chloroaniline is used in the synthesis of 2-Azetidinones which is a well-renowned heterocyclic compound amongst organic and medicinal chemists. Biological activities of these compounds include antimicrobial anti-tubercular, carbonic anhydrase inhibitors, local anesthetics, anti-inflammatory, anthelmintic, anticonvulsant, hypoglycemic agents activity.
References
Vijayakumar M M J et al. “Synthesis and Characterization of Novel N-Substituted-3-Chloro-2-Azetidinones as Potential Anticonvulsant Agents.†J Biomed Sci and Res., vol. Vol 1, no. 1, 2009, pp. 1–10, http://citeseerx.ist.psu.edu/viewdoc/download?doi=10.1.1.1069.2612&rep=rep1&type=pdf
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