Empagliflozin Methoxy Impurity(CAS 872980-38-6)는 empagliflozin 합성 경로와 연관된 공정 유래 불순물로, 방향족 산소 기능기의 O-메틸화 또는 메탄올 매개 부반응에 의해 형성될 수 있는 구조적 유사체이다. 분자식 C28H31ClO10, 분자량 563 g/mol의 이 화합물은 염소화된 다산소화 글리코사이드 유도체로서, 높은 극성과 다수의 입체중심 때문에 크로마토그래피 분리가 까다롭다. 극미량 정량에는 일반적으로 역상 HPLC와 다이오드 어레이 검출, 추가로 LC-MS/MS 또는 고분해능 MS를 이용한 질량 확인이 요구된다. 변이원성 경고 구조를 가진 화학종은 아니므로, 평가는 주로 불순물 프로파일링과 개발 및 안정성 연구에서의 규격 설정에 초점이 맞춰진다.
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