Osimertinib N-Oxide(CAS 2411395-22-5)는 quinazoline 기반 EGFR 억제제인 osimertinib의 N-산화 유도체로, 분자식 C28H33N7O3, 분자량 515.61 g/mol이다. 이 불순물은 산화 스트레스, 과산화물 노출, 또는 dimethylamino 측쇄의 대사적 N-oxygenation 과정에서 형성될 수 있다. N-oxide 작용기는 극성, 머무름 거동, 이온화 반응을 변화시키므로 LC-MS/MS, 고분해능 질량분석, 필요 시 NMR에 의한 교차 확인이 요구된다. 불순물 프로파일링에서는 안정성 지시 조건하에서 공정 관련 및 분해 관련 종으로 평가된다.
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