Rivaroxaban Impurity 38, CAS 1082588-73-5는 분자식 C10H12N2O2, 분자량 192.21 g/mol의 저분자 헤테로방향족 불순물에 해당한다. 이 조성은 작은 극성 골격을 시사하며, 전형적인 니트로사민 또는 니트로소 유도체라기보다 리바록사반 관련 중간체의 합성 경로, 측쇄 절단, 또는 산화적 변환 과정에서 생성될 수 있다. 규제 평가에서는 구조적 경고신호, 잠재적 변이원성, 물질수지상 중요성이 검토된다. 미량 수준의 규명과 정량에는 통상 LC-MS/MS와 고해상도 MS 확인이 요구되며, 휘발성과 유도체화 가능성이 있을 경우 LC-UV 또는 GC-MS와 같은 보완적 방법이 사용된다.
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