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포함 사항: HPLC, MASS/LC-MS, 1H NMR, FT-IR, 함량, 구조 규명 보고서(SER), 그리고 제품에 따라 추가 분석 데이터가 제공됩니다.

2768445-19-6Upadacitinib Trifluoroacetamide Impurity

● 재고 있음

카탈로그 번호:	VE0027858
CAS 번호:	2768445-19-6
분자식:	C23H22F3N5O3S
분자량:	505.51 g/mol

견적 요청

RFQ 목록에 추가

에 대한 추가 정보 CAS 2768445-19-6

모약물

Upadacitinib

IUPAC명

1-((3S,4R)-3-ethyl-4-(3-tosyl-3H-imidazo[1,2-a]pyrrolo [2,3-e]pyrazin-8-yl) pyrrolidin-1- yl)-2,2,2-trifluoroethanone

Pharmacopeial Synonyms

N/A

동의어

N/A

SMILES

FC(F)(F)C(N1C[C@@H](CC)[C@@H](C2=CN=C3C=NC(N(S(=O)(C4=CC=C(C)C=C4)=O)C=C5)=C5N32)C1)=O

InChI

InChI=1S/C23H22F3N5O3S/c1-3-15-12-29(22(32)23(24,25)26)13-17(15)19-10-27-20-11-28-21-18(31(19)20)8-9-30(21)35(33,34)16-6-4-14(2)5-7-16/h4-11,15,17H,3,12-13H2,1-2H3/t15-,17+/m1/s1

설명

Upadacitinib Trifluoroacetamide Impurity (CAS 2768445-19-6) is a process-related byproduct formed during trifluoroacetylation steps in Upadacitinib synthesis, requiring targeted analytical characterization and control. This impurity exhibits distinct mass and 19F NMR signatures enabling detection by LC-MS and fluorine-sensitive NMR methods, while HPLC with appropriate reference standards supports quantitation. Relevant quality considerations include establishment of identification thresholds, qualification limits per ICH Q3A/B, forced degradation studies to assess stability, and implementation of purification or process adjustments to minimize carryover. Accurate profiling of this impurity is essential for regulatory submissions and consistent drug substance quality.